Endocrine Abstracts

Obesity has been associated with a status of subclinical inflammation. Neutrophil to lymphocyte ratio (NRL) is a widely available and inexpensive inflammatory marker which can be reliable in evaluating the inflammatory status occurring in patients with severe obesity The aim of our study was to investigate the association between NLR and anthropometric and body-composition parameters, in a group of patients with obesityPatients and Methods: 737 patients ...

Background: Malignancy and hyperthyroidism used to be considered mutually exclusive, but increased association was observed. These two conditions incidence is variable, ranging between 0 and 9%, Graves’ disease is especially linked to differentiated thyroid carcinoma type.Case presentation: We report the case of a 33 year old, female, smoker, diagnosed with Basedow–Graves disease in may 2015, on methimazole 20 mg/day. She was admitted to our de...

Introduction: Decreased bone mass is associated with inflammatory bowel disease (IBD), due to multiple factors, including endocrine disturbances, deficits in calcium and vitamin D, malnutrition, drugs (corticosteroids), chronic inflammation. If in older man and postmenopausal women, the treatment is well established, for young patients is not a general consensus.Case report: We report the case of a 20-year-old, male, nonsmoker, diagnosed with Crohn disea...

Introduction: Ipilimumab is an efficient medication used for the management of melanoma. However, it has been associated with endocrine dysfunctions such as hypophysitis, thyroid disorders (hypo- or hyperthyroidism), and adrenal insufficiency.Case report: We report the case of a 65-year-old male diagnosed with melanoma (Clark V). In 2022, he was operated and received treatment with ipilimumab 3 mg/kg. Three weeks after t...

Introduction: Vitamin D is a potential immune modulator and low levels are common in inflammatory bowel disease (IBD) patients. The aim of the study was to determine the association between deficient vitamin D and inflammatory profile.Methods: Intestinal (fecal calprotectin) and blood inflammatory profile [erythrocytes sedimentation rate (ESR), protein C reactive, fibrinogen], were performed to all patients. In addition, level of 25 hydroxy vitamin D was...

Introduction: Although patients with inflammatory bowel disease (IBD) -Crohn’s disease (CD) and ulcerative colitis (UC)- are considered prone to malnutrition, studies have shown an increased risk for obesity, especially visceral obesity and metabolic syndrome (MetS). Possible mechanisms involved include dysbiosis, gut microbiome and chronic inflammation. The aim of the study was to assess the prevalence of MetS and obesity in a group of IBD patients.<p class="abstext"...

Introduction: Patients with inflammatory bowel disease (IBD) are at increased risk for decreased bone mass density (BMD), fractures. Preserved muscle mass is important for healthy bones. Low mean mass can be found in these patients due to immobilization, lack of physical activity and glucocorticoids. Our aim was to evaluate the presence of low BMD and muscle mass impact on it.Methods: 64 patients with inflammatory bowel disease (40 with Crohn disease, 24...

Background: A large body of evidences have demonstrated that metabolic surgery is associated with significant and durable weight loss as well as a significant improvement of obesity-related comorbidities. The aim of our study was to evaluate the long term impact of gastric sleeve on metabolic parameters in morbidly obese patients.Materials and methods: We evaluated 95 (67 women) severely obese patients (mean age 43.4±10.69 years) before and approxim...

Background: Glucocorticoid-induced osteoporosis is common in chronic diseases as inflammatory bowel disease. Although BMD (bone mass density) is used for the estimation of the quantity of the bone, on the contrary, TBS (trabecular bone score) is a new parameter, a gray-level textural assessment of bone microarchitecture, providing estimation of quality of bone. Several studies showed increased level of TBS during teriparatide treatment in glucocorticoid induced osteoporosis.</...

Background: Pituitary surgery is the first treatment option for acromegaly. The reported success of pituitary surgery varies between 75 and 95% for microadenomas and 45 and 68% for macroadenomas. The aim of this study was to report our experience regarding the remission rate after pituitary surgery in acromegaly patients.Methods: This retrospective study included 70 patients diagnosed with acromegaly in our clinic between 2009 and 2016. The criteria used...